Crystalline n-formyl hydroxylamine compounds

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 401/12 (2006.01) A61K 31/4439 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2520682

Certain N-formyl hydroxylamine compounds, such as N-[1-oxo-2-alkyl-3-(N- hydroxyformamido)-propyl]-(carbonylamino-aryl or -heteroaryl)-azacyclo4- 7alkanes or thiazacyclo4-7alkanes or imidazacycIo4-7alkanes are useful in the treatment of bacterial infections. Disclosed are crystalline salts of such compounds of formula (I), wherein M is a mono- or di-valent metal; a is ~ or 1.

Certains composés <I>N</I>-formyl-hydroxylamine tels que les composés <I>N</I>-[1-oxo-2-alkyl-3-(N-hydroxyformamido)-propyl]-(carbonylamino-aryl ou -hétéroaryl)-azacyclo¿4-7?alcanes ou thiazacyclo¿4-7?alcanes ou imidazacyclo¿4-7?alcanes peuvent être utilisés pour traiter des infections bactériennes. La présente invention se rapporte à des sels cristallins de ces composés de formule (I), dans laquelle : M représente un métal monovalent ou bivalent ; a est égal à ? ou 1.

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