C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/10 (2006.01) A61P 19/08 (2006.01) A61P 25/28 (2006.01) A61P 31/00 (2006.01) A61P 33/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) A61P 37/06 (2006.01) C07D 303/36 (2006.01) C07K 5/107 (2006.01)
Patent
CA 2701778
The invention relates to crystalline peptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions. This invention also relates to methods for the preparation of amino acid keto-epoxides. Specifically, allylic ketones are stereoselectively converted to the desired keto epoxides.
L'invention concerne des composés céto-époxydes peptidiques cristallins, des procédés d'élaboration et des compositions pharmaceutiques connexes, ainsi que des procédés d'élaboration de céto-époxydes d'acides aminés. Spécifiquement, des cétones allyliques sont converties de façon stéréosélective en céto-époxydes spécifiques.
Fuller William Dean
Laidig Guy J.
Phiasivongsa Pasit
Sehl Louis C.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Onyx Therapeutics Inc.
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