Crystalline polymorphs of a cxc-chemokine receptor ligand

Details Crystalline polymorphs of a cxc-chemokine receptor ligand Crystalline polymorphs of a cxc-chemokine receptor ligand

C - Chemistry, Metallurgy

07

D

C07D 307/52 (2006.01) A61K 31/341 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2554709

The present invention relates to four distinct crystalline polymorphs of a monohydrate of Compound A having the following chemical structure (A). These four polymorphic forms, herein referred to as Forms I, II, III and IV are active as a CXC-chemokine receptor ligands. The invention is further directed to formulations, methods of treatment, and processes of synthesis of these polymorphic forms.

La présente invention porte sur quatre polymorphes cristallins distincts d'un monohydrate du composé A ayant la structure chimique suivante (A). Ces quatre formes polymorphiques, appelées iciFormes I, II, III et <I>IV </I>sont actives telles que le ligand du récepteur des CXC-chimiokines. L'invention porte également sur des formulations, sur des méthodes de traitement et sur des procédés de synthèse de ces formes polymorphiques.

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