Crystalline progestagens

Details Crystalline progestagens Crystalline progestagens

C - Chemistry, Metallurgy

07

J

C07J 7/00 (2006.01) A61K 31/57 (2006.01) C07J 1/00 (2006.01)

Patent

CA 2244619

The disclosed invention resides in the polymorphism found with the progestagenic steroidal compound (17.alpha.)-17-hydroxy-11-methylene-19-norpregna-4,15-diene-20-yn-3-one. More particularly, the invention resides in crystalline forms of said compound having unexpectedly favourable thermodynamic stability. These crystalline compounds, which can be suitably described with reference to spectral data, can advantageously be employed as an active ingredient in solid pharmaceutical compositions. The crystalline compounds can be used in oral contraceptives and in hormone replacement therapy (HRT).

L'invention porte sur le polymorphisme observé dans le cas du composé stéroïdien progestagène (17-alpha)-17-hydroxy-11-méthylène-19-norprégna-4,15-dién-20-yn-3-one. L'invention porte plus précisément sur les formes cristallisés dudit composé, possédant une stabilité thermodynamique étonnamment avantageuse. Ces composés cristallisés, qui peuvent être décrits de façon appropriée par leurs données spectrales, peuvent être employés avantageusement comme ingrédients actifs dans des compositions pharmaceutiques solides. Les composés cristallisés peuvent servir dans des contraceptifs oraux et en hormonothérapie.

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