Crystalline quinapril and a process for producing the same

Details Crystalline quinapril and a process for producing the same Crystalline quinapril and a process for producing the same

C - Chemistry, Metallurgy

07

D

260/284

C07D 217/26 (2006.01)

Patent

CA 1291999

ABSTRACT A novel crystalline form of quinapril and a novel process for the large scale preparation of the ACE inhibitor, quinapril, in a highly pure state. The substance is of high bulk density suitable for formulation in capsules and tablets. This inexpensive process uses HCl gas in glacial acetic acid for rapid and clean de-t-butylation at room temperature.

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