C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 261/04 (2006.01) A61K 31/42 (2006.01)
Patent
CA 2294047
The potent platelet glycoprotein IIb/IIIa antagonist, roxifiban, is produced in crystalline form. Crystalline roxifiban exists in two polymorphic forms, designated Form 1 and Form 2. These polymorphic forms are characterized by x- ray powder diffraction and solid-state carbon NMR. Pharmaceutical compositions and methods for the treatment or prevention of diseases mediated by platelet aggregation are described.
L'antagoniste puissant de la glycoprotéine IIb/IIIa thrombocytaire, le roxifiban, est produit sous forme cristalline. Le roxifiban cristallin existe sous deux formes polymorphes, désignées Forme 1 et Forme 2. Ces formes polymorphes se caractérisent par une diffraction des rayons X sur poudre et une résonance magnétique nucléaire au carbone à l'état solide. L'invention concerne également des compositions et des thérapies destinés à la prévention ou au traitement de maladies associées à l'agrégation plaquettaire.
Ma Philip
Maurin Michael B.
Meloni David J.
Pesti Jaan A.
Rossano Lucius T.
Bristol-Myers Squibb Pharma Company
Dimock Stratton Clarizio Llp
Dupont Pharmaceuticals Company
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