Crystalline salt forms of antifolate compounds and methods...

Details Crystalline salt forms of antifolate compounds and methods... Crystalline salt forms of antifolate compounds and methods...

C - Chemistry, Metallurgy

07

D

C07D 239/95 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2718544

The present invention provides methods of preparing antifolate compounds according to the formula depicted be-low. The inventive methods can particularly be use for preparing compounds exhibiting improved bioavailability, making the compound particularly useful in pharmaceutical compositions. The compounds prepared according to the inventive methods are useful in the treatment of multiple conditions, including abnormal cell proliferation, inflammatory diseases, asthma, and arthritis.

La présente invention porte sur des procédés de préparation de composés antifolates selon la formule représentée ci-après. Les procédés de l'invention peuvent en particulier être utilisés pour préparer des composés présentant une biodisponibilité améliorée, rendant le composé particulièrement utile dans des compositions pharmaceutiques. Les composés préparés selon les procédés de l'invention sont utiles dans le traitement de multiples conditions, comprenant une prolifération cellulaire anormale, des maladies inflammatoires, l'asthme et l'arthrite.

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