Crystalline salts of [3s(z)]-2[[[1-(2-amino-...

Details Crystalline salts of [3s(z)]-2[[[1-(2-amino-... Crystalline salts of [3s(z)]-2[[[1-(2-amino-...

C - Chemistry, Metallurgy

07

D

167/180, 260/302

C07D 417/12 (2006.01) C07H 17/08 (2006.01) A61K 31/71 (1990.01)

Patent

CA 1296717

CRYSTALLINE SALTS OF [3S(Z)]1-2[[[1- (2-AMINO-4-THIAZOLYL)-2-[[2,2-DIMETHYL-4- OXO-l-(SULFOOXY)-3-AZETIDINYL]AMINO]-2- OXOETHYLIDENE]-AMINO]OXY]ACETIC ACID Abstract of the Disclosure In accordance with the present invention an orally active monosulfactam antibiotics having a crystalline structure and thereby improved stability are disclosed. The antibiotics comprise the dierythromycin (M? = erythromycin?H?) salt or the dicholine (M? = HOCH2CH2N?(CH3)3) salt of the acid (M? = H?) having the formula Image that is, [3S(Z)]-2[[[1-(2-amino-4-thiazolyl)-2- [[2,2-dimethyl-4-oxo-l-(sulfooxy)-3-azetidinyl]- amino]-2-oxoethylidene]amino]oxy]acetic acid.

554563

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