Crystalline solid and amorphous forms of (-)- halofenate

Details Crystalline solid and amorphous forms of (-)- halofenate Crystalline solid and amorphous forms of (-)- halofenate

C - Chemistry, Metallurgy

07

C

C07C 233/18 (2006.01) A61K 31/216 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) C07C 231/24 (2006.01)

Patent

CA 2606279

The present invention provides crystalline solid and amorphous forms of (-)- halofenate. The crystalline solid forms may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of conditions associated with blood lipid deposition in a mammal, particularly those diseases related to Type 2 diabetes and hyperlipidemia. The invention also relates to a method for preventing or treating Type 2 diabetes and hyperlipidemia in a mammal comprising the step of administering a therapeutically effective amount of crystalline solid and amorphous forms of (- )-halofenate.

L'invention concerne des formes cristallines solides et amorphes de (-)-halofénate. On peut utiliser lesdites formes cristallines solides dans des compositions pharmaceutiques variées, ces formes cristallines étant particulièrement efficaces pour prévenir et/ou traiter des états associés à un dépôt de lipides sanguins chez un mammifère, notamment, les maladies associées au diabète de type 2 diabètes et à l'hyperlipémie. L'invention concerne également une méthode permettant de prévenir et de traiter le diabète de type 2 et l'hyperlipémie chez un mammifère, qui consiste à administrer une quantité thérapeutiquement efficace de formes cristallines solides et amorphes de (-)-halofénate.

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