C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 38/17 (2006.01) B01D 9/02 (2006.01) C12N 15/09 (2006.01) G01N 23/223 (2006.01) G01N 33/68 (2006.01) G06F 17/50 (2006.01)
Patent
CA 2713884
The invention relates to a crystal of the CC2-LZ domain of the NEMO protein, in which the three-dimensional structure has been determined by X-ray diffraction at a resolution of about 3.25 A. The invention also relates to methods for the crystallisation of the CC2-LZ domain. The CC2-LZ crystals and the information derived from the crystalline structures thereof are used for identifying and designing compounds interacting with CC2-LZ.
Cristal du domaine CC2-LZ de la protéine NEMO dont la structure tri- dimensionnelle a été déterminée par diffraction des rayons X à une résolution d'environ 3.25 A. La présente invention concerne également des méthodes de cristallisation du domaine CC2-LZ. Les cristaux de CC2-LZ ainsi que l'information dérivés de leurs structures cristallines sont utilisés pour identifier et concevoir des composés qui entrent en interaction avec CC2-LZ.
Agou Fabrice
Chiaravalli Jeanne
Cordier Florence
Duquerroy Stephane
Fontan Elisabeth
Institut Pasteur
Les Laboratoires Servier
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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