C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/22 (2006.01) A61K 9/48 (2006.01) A61K 31/4745 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2545876
Disclosed is a novel crystalline form of topotecan monohydrochloride pentahydrate, which is a pentahydrate of 10-[(dimethylamino)methyl]-4-ethyl- 4,9-dihydroxy-1H-pyrano[3~,4~: 6,7]indolizino[1,2-b]quinoline- 3,14(4H,12H)dione monohydrochloride, corresponding pharmaceutical compositions, methods preparation and/or use thereof to treat anti-viral and/or cancer-related diseases.
Cette invention concerne une nouvelle forme cristalline de topotécan monohydrochloride pentahydrate, qui est un pentahydrate de 10-[(diméthylamino)méthyl]-4-éthyl-4,9-dihydroxy-1H-pyrano[3',4': 6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione monohydrochlorure, des compositions pharmaceutiques correspondantes, des procédés de fabrication et/ou des méthodes d'utilisation pour le traitement de maladies virales et/ou associées au cancer.
Dell'orco Philip C.
Diederich Ann Marie
Su Qiaogang
Wood Jeffery Lee
Gowling Lafleur Henderson Llp
Smithkline Beecham (cork) Limited
Smithkline Beecham Corporation
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