Crystalline trimetrexate salts and the process for making...

Details Crystalline trimetrexate salts and the process for making... Crystalline trimetrexate salts and the process for making...

C - Chemistry, Metallurgy

07

D

C07D 239/95 (2006.01) C07H 7/033 (2006.01)

Patent

CA 2210252

The present invention provides for a crystalline form of trimetrexate either as a glucuronate, acetate, hydrochloride, methanosulfonate or lactate salt, which can be processed galenically as a stable, well-defined solid substance and processes for producing the crystalline forms. Such crystalline forms allow for prolonged stability in storage and for oral and intravenous administration of the drug.

L'invention concerne une forme cristalline de sels de trimétrexate, soit en tant que glucuronate, acétate, hydrochlorure, méthanosulfonate, soit en tant que lactate, qu'on peut traiter galéniquement en tant que substance stable, solide et bien définie, ainsi que des procédés d'obtention des formes cristallines. Ces formes permettent de prolonger la stabilité de conservation du médicament et de l'administrer par voie orale ou intraveineuse.

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