Crystalline vap-1 and uses thereof

Details Crystalline vap-1 and uses thereof Crystalline vap-1 and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 9/00 (2006.01) B01D 9/00 (2006.01)

Patent

CA 2526675

The present invention relates to crystalline vascular adhesion protein-1 (VAP- 1) and in particular to methods for the use of structural information of crystalline human VAP-1 for ligand and/or inhibitor identification, design and production, as well as screening assays for detection of same. The invention further relates to inhibitors identified by the assays according to the present invention.

L'invention concerne la protéine d'adhésion vasculaire cristalline 1 (VAP-1), et notamment des procédés permettant d'utiliser les informations structurales relatives à la VAP-1 cristalline humaine pour identifier, concevoir et produire des ligands et/ou inhibiteurs, ainsi que des méthodes de criblage servant à détecter ces derniers. La présente invention se rapporte en outre à des inhibiteurs identifiés au moyen des méthodes de criblage selon l'invention.

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