C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 217/74 (2006.01) C07C 213/00 (2006.01)
Patent
CA 2468728
The present invention relates to novel essentially pure venlafaxine and the process of preparation thereof. The present invention also relates to novel solvate forms of venlafaxine hydrochloride and the process of preparation thereof. Furthermore, the present invention provides a novel process for preparing venlafaxine hydrochloride from venlafaxine; the process comprises the steps of: i) preparing a mixture of venlafaxine with acetone; and ii) exposing the mixture in gaseous hydrochloric acid.
La présente invention concerne une nouvelle venlafaxine essentiellement pure et le procédé de préparation de cette dernière. L'invention concerne également de nouvelles formes solvates du chlorhydrate de venlafaxine et le procédé de préparation de ces dernières. L'invention se rapporte en outre à un nouveau procédé permettant de préparer du chlorhydrate de venlafaxine à partir de la venlafaxine, selon lequel : i) on prépare un mélange de venlafaxine et d'acétone ; et ii) on expose ledit mélange à de l'acide chlorhyrique gazeux.
Aronhime Judith
Dolitzky Ben-Zion
Nisnevich Gennady A.
Wizel Shlomit
Heenan Blaikie Llp
Teva Pharmaceutical Industries Ltd.
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