A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/14 (2006.01) A61J 3/02 (2006.01) A61K 9/16 (2006.01) A61K 9/72 (2006.01) A61K 31/167 (2006.01) A61P 11/00 (2006.01) A61P 29/00 (2006.01) A61P 37/08 (2006.01)
Patent
CA 2348084
The invention provides a process for preparing essentially crystalline particles containing a substance in solvated form, by dissolving the substance in a first solvent, introducing the solution and a supercritical or subcritical fluid into an apparatus, wherein the fluid contains an anti-solvent and a second solvent, which is water. Preferably, the anti- solvent is carbon dioxide which is totally saturated with the second solvent, which is water. The invention further provides formulations comprising particles produced according to the present process containing one or more pharmacologically active substances and one or more pharmaceutically acceptable excipients, use of said formulations in the treatment of an allergic and/or inflammatory condition of the nose or lungs and methods for treatment of such conditions.
L'invention concerne un procédé de préparation de particules cristallines essentiellement contenant une substance sous forme solvatée. Ledit procédé consiste à dissoudre ladite substance dans un premier solvant, et introduire la solution et un liquide supercritique ou sous-critique dans un appareil. Ledit fluide contient un antisolvant et un second solvant, soit de l'eau. De préférence, l'antisolvant est le dioxyde de carbone qui est totalement saturé du second solvant, soit de l'eau. L'invention concerne en outre des formulations comprenant des particules produites selon ledit procédé, qui contiennent au moins une substance pharmacologiquement active et au moins un excipient pharmaceutiquement acceptable, ainsi que l'utilisation desdites formulations dans le traitement d'un état allergique et/ou inflammatoire du nez ou des poumons, et des procédés de traitement de tels états.
Bisrat Mikael
Demirbuker Mustafa
Moshashee Saeed
Nyqvist Hakan
Astrazeneca Ab
Smart & Biggar
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