Crystallizable compositions comprising a hepatitis c virus...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/18 (2006.01) C07K 1/00 (2006.01) C30B 7/00 (2006.01) G01N 33/576 (2006.01) G06F 17/50 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2264964

The present invention relates to compositions and crystals of a hepatitis C virus protease in complex with its viral cofactor. This invention also relates to methods of using the structure coordinates of hepatitis C virus protease in complex with a synthetic NS4A to solve the structure of similar or homologous proteins or protein complexes.

Compositions et cristaux de protéase du virus de l'hépatite C associé en complexe avec son cofacteur viral. On décrit aussi des procédés relatifs à l'utilisation des coordonnées de structure de la protéase du virus de l'hépatite C, en complexe avec un NS4A synthétique, pour résoudre les problèmes liés à la structure de protéines ou de complexes de protéines similaires ou homologues.

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