Crystallization method and apparatus using an impinging...

A - Human Necessities – 61 – K

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A61K 9/00 (2006.01) A61K 9/14 (2006.01) B01D 9/00 (2006.01)

Patent

CA 2500535

A crystallization process for generating a pharmaceutical product from solutions of pharmaceutically active compounds or their reactive intermediates employs fluid jet streams containing pharmaceutically active ingredients, appropriate anti-solvents and/or their reactive intermediates capable of producing a pharmaceutical product with desired particle size characteristics upon mixing, chemical reaction, nucleation and precipitation. The jet streams are directed towards and impinging plate, and mixing occurs as the jet streams impinge the plate at a desired area of impact.

Procédé de cristallisation servant à générer un produit pharmaceutique à partir de solutions de composés actifs sur le plan pharmaceutique ou de leurs intermédiaires réactifs et mettant en application des jets de liquide contenant des ingrédients actifs sur le plan pharmaceutique, des anti-solvants appropriés et/ou leurs intermédiaires réactifs capables de générer un produit pharmaceutique présentant des caractéristiques désirées de dimension de particule par mélange, réaction chimique, nucléation et précipitation. Ces jets de liquide sont dirigés vers une plaque de choc et leur mélange s'effectue simultanément au choc de ces jets de liquide au niveau d'une zone d'impact désirée.

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