Crystallization of ibuprofen

C - Chemistry – Metallurgy – 07 – C

Patent

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260/516.8, 260/5

C07C 57/30 (2006.01)

Patent

CA 1212693

ABSTRACT OF THE DISCLOSURE Ibuprofen is crystallized from a .delta.H > 8 liquid such as a C1 to C3-alkanol, e.g., methanol, containing solutions thereof to obtain ibuprofen crystals which are equant (cube, sphere or grain) in shape, which ibuprofen crystals have larger average particle size, higher bulk density, lower bulk volume and improved flow properties compared to previously known bulk ibuprofen crystalline materials.

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