Crystallization of iodixanol in isopropanol and methanol

Details Crystallization of iodixanol in isopropanol and methanol Crystallization of iodixanol in isopropanol and methanol

C - Chemistry, Metallurgy

07

C

C07C 231/24 (2006.01) C07C 237/46 (2006.01)

Patent

CA 2707173

A process for the manufacture of iodixanol by performing a crystallization process of the crude product in a solvent mixture comprising water, methanol and isopropanol. The crude product may be obtained in aqueous solution from dimerisation of 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6- triiodo-isophthalamide ("Compound A").

Procédé pour la fabrication d'iodixanol par cristallisation du produit brut dans un mélange de solvants composé d'eau, de méthanol et d'isopropanol. Le produit brut peut être obtenu en solution aqueuse par dimérisation de 5-acétamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6- triiodo-isophtalamide (« composé A »).

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