Crystallization system utilizing atomization

B - Operations – Transporting – 01 – D

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B01D 9/00 (2006.01) A61K 9/16 (2006.01) B01F 3/08 (2006.01) B01F 5/02 (2006.01) B01J 19/00 (2006.01) B01J 19/10 (2006.01) B01J 19/18 (2006.01) B01J 19/24 (2006.01) B01J 19/26 (2006.01) C07D 263/00 (2006.01) B01F 7/00 (2006.01)

Patent

CA 2484212

Crystallization of an organic pharmaceutical compound is achieved by atomization of one solution and introduction of the atomized solution into a vessel containing a second solution where the solutions are mixed to form a product. The process can be performed on non-reactive constituents such as a solution containing the compound to be crystallized dissolved in a solvent and an anti-solvent solution. Alternatively, the process can be performed on reactive constituents, such as solutions of solvents containing different reactive intermediates, under proper reactive conditions. The process may be practiced continuously or in batch mode. Atomizers of the non-pressure-driven ultrasonic type or of the ultrasonic or non-ultrasonic pressure-driven type can be utilized.

La cristallisation d'un composé pharmaceutique organique est effectuée par l'atomisation d'une solution et l'introduction de la solution atomisée dans un récipient contenant une seconde solution, ces solutions étant mélangées de façon à former un produit. Le procédé peut être effectué sur des constituants non réactifs tels qu'une solution contenant le composé à cristalliser dissous dans un solvant et une solution anti-solvant. En variante, le procédé peut être effectué sur des constituants réactifs tels que des solutions de solvants contenant différents intermédiaires réactifs dans des conditions de réaction correctes. Le procédé peut être pratiqué en continu ou en mode différé. On peut utiliser des atomiseurs de type ultrasonique à pression atmosphérique ou de type ultrasonique ou à pression non ultrasonique.

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