C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61P 37/08 (2006.01) C07K 14/735 (2006.01) G01N 33/566 (2006.01) G06T 17/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2349410
The present invention includes three-dimensional models of antibody receptor proteins, such as Fc.epsilon.RI.alpha. proteins, and methods to produce such models. The present invention also includes muteins having increased stability and/or antibody binding activity, as well as methods to produce such muteins, preferably using information derived from three-dimensional models of the present invention. Also included are nucleic acid sequences encoding muteins of the present invention and use of those sequences to produce such muteins. Also included is the use of the model to identify compounds that inhibit the binding of an antibody receptor protein to an antibody. The present invention also includes uses of such muteins and inhibitory compounds, for example, in methods to diagnose and protect animals from allergy and other abnormal immune responses.
L'invention concerne des modèles tridimensionnels de protéines réceptrices d'anticorps, telles que les protéines Fc.epsilon.RI.alpha., ainsi que des procédés de production de ces modèles. L'invention concerne également des mutéines à stabilité améliorée et/ou à activité de liaison d'anticorps ainsi que des procédés de production de ces mutéines, de préférence au moyen d'informations issues des modèles tridimensionnels selon l'invention. L'invention concerne également des séquences d'acide nucléique codant pour les mutéines selon l'invention ainsi que l'utilisation des ces séquences pour produire ces mutéines. L'invention concerne également l'utilisation du modèle pour identifier des composés inhibant la liaison d'une protéine réceptrice d'anticorps à un anticorps. L'invention concerne enfin les utilisations des ces mutéines et des ces composés inhibiteurs, par exemple, dans des procédés destinés à diagnostiquer chez des animaux des allergies et d'autres réactions immunitaires anormales et à les en protéger.
Garman Scott Clayton
Jardetzky Theodore S.
Kinet Jean-Pierre
Borden Ladner Gervais Llp
Heska Corporation
Northwestern University
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