Crystallographically stable amorphous cephalosporin...

A - Human Necessities – 61 – K

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A61K 31/546 (2006.01) A61K 9/14 (2006.01) A61K 47/30 (2006.01) A61K 47/38 (2006.01) C07D 501/24 (2006.01)

Patent

CA 2316841

Yellow and powdery compositions consisting of particles composed of a homogeneous mixture of amorphous cefditoren pivoxil with a water-soluble polymer additive and being orally administrable. These compositions can be obtained by dissolving the amorphous cefditoren pivoxil and the water-soluble polymer in an aqueous solution of an acid, neutralizing, coprecipitating, and then drying the thus obtained precipitate followed by the recovery of the product.

L'invention concerne des compositions jaunes et poudreuses comprenant un mélange homogène de cefditoren pivoxil amorphe et d'un additif polymère soluble à l'eau, ces compositions se prêtant à une administration par voie orale. On peut préparer ces compositions par une dissolution des ingrédients ci-dessus dans un acide, suivie d'une neutralisation, d'une co-précipitation puis du séchage du précipité résultant et enfin de la récupération du produit.

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