Crystals and structures of c-abl tyrosine kinase domain

Details Crystals and structures of c-abl tyrosine kinase domain Crystals and structures of c-abl tyrosine kinase domain

C - Chemistry, Metallurgy

12

N

C12N 9/12 (2006.01) C12Q 1/48 (2006.01) C40B 30/02 (2006.01) C40B 50/02 (2006.01) G01N 25/14 (2006.01) G06F 17/30 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2525681

The present invention provides machine readable media embedded with the three~dimensional molecular structure coordinates of Ab1KD and variants and subsets thereof, including binding pockets, methods of using the structure to identify and design affecters, including inhibitors and activator Ab1KD crystals and compounds and compositions that affect Abl activity.

L'invention concerne des supports lisibles par un ordinateur intégrés aux coordonnées de structure moléculaire tridimensionnelle de AblKD et des variants et des sous-ensembles associés, notamment des poches de liaison; des procédés d'utilisation de cette structure permettant d'identifier et d'élaborer des agents qui exercent une action, notamment des inhibiteurs et des activateurs de cristaux AblKD ainsi que des composés et des compositions qui affectent l'activité de l'Abl.

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