Crystals of prasugrel hydrobromate

C - Chemistry – Metallurgy – 07 – D

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C07D 495/04 (2006.01) A61K 31/4365 (2006.01) A61P 7/02 (2006.01)

Patent

CA 2757189

The present application discloses crystals of 2-acetoxy-5-(.alpha.-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7- tetrahydrothieno[3,2-c]p yridine hydrobromate, crystal compositions and pharmaceutical compositions comprising them and their use. The crystals of prasugrel hydrobromate of the present application possess excellent stability and solubility.

Cette invention concerne des cristaux de bromhydrate de 2-acétoxy-5- (a-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tétrahydrothiéno[3,2-c]- pyridine, des compositions cristallines et des compositions pharmaceutiques les contenant et leur utilisation. Les cristaux de bromhydrate de prasugrel selon la présente demande possèdent une excellente stabilité et solubilité.

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