Crystals of quinolinecarboxylic acid derivative solvate

C - Chemistry – Metallurgy – 07 – D

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07D 513/04 (2006.01) A61K 31/496 (2006.01) A61P 31/04 (2006.01) B01D 9/02 (2006.01)

Patent

CA 2523854

The invention aims at providing crystals of 6-fluoro-1-methyl-7-[4-(5-methyl-2- oxo-1,3-dioxolen-4-yl)- methyl-1-piperazinyl]-4-oxo-4H-[1,3]thiazeto[3,2- a]quino- line-3-carboxylic acid acetonitrile solvate (compound B) which are useful as an intermediate for producing preferentially III-type crystals of 6- fluoro-1-methyl-7-[4-(5-methyl-2-oxo -1,3-dioxolen-4-yl)methyl-1-piperazinyl]- 4-oxo-4H-[1,3]- Thiazeto[3,2-a]quinoline-3-carboxylic acid (compound A). Compound B can be preferentially crystallized from acetonitrile by controlling the supersaturation concentration, and desolvation of the crystals of compound B can give III-type crystals of compound A.

L'invention concerne la production de cristaux de 6-fluoro-1-méthyl-7-[4-(5-méthyl-2-oxo-1,3-dioxolène-4-yl)-méthyl-1-piperazinyl]-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-solvate d'acétonitrile d'acide carboxylique (composé B) qui sont utilisés comme intermédiaire dans la production préférentielle de cristaux de type III de 6-fluoro-1-méthyl-7-[4-(5-méthyl-2-oxo-1,3-dioxolène-4-yl)-méthyl-1-piperazinyl]-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-acide carboxylique (composé A). Ledit composé B peut être, de préférence, cristallisé à partir d'acétonitrile par régulation de la concentration de supersaturation et, en outre, la dissolution des cristaux du composé B peut engendrer des cristaux de type III du composé A.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Crystals of quinolinecarboxylic acid derivative solvate does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Crystals of quinolinecarboxylic acid derivative solvate, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Crystals of quinolinecarboxylic acid derivative solvate will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1519840

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.