Crystals of the alpha 1 beta 1 integrin i-domain and their use

Details Crystals of the alpha 1 beta 1 integrin i-domain and their use Crystals of the alpha 1 beta 1 integrin i-domain and their use

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) C30B 7/04 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2340333

The present invention relates to crystals of fragments of alpha 1 beta 1 integrin (".alpha.1.beta.1"), specifically, a soluble fragment of the .alpha.1 chain of .alpha.1.beta.1 integrin (143-340). The invention relates further to uses of these crystals and the coordinates thereof to design, identify, optimize or characterize chemical entities having properties of interest.

La présente invention concerne des cristaux de fragments d'alpha 1 bêta 1 intégrine (".alpha.1.beta.1"), notamment, un fragment soluble de la chaîne .alpha.1 de .alpha.1.beta.1 intégrine (143-340). L'invention concerne également les utilisations de ces cristaux et de leurs liaisons de coordination pour concevoir, identifier, optimiser et caractériser les entités chimiques possédant des propriétés d'intérêt.

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