Cs-1 peptidomimetics, compositions and methods of using the...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 5/08 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 5/072 (2006.01) C07K 5/083 (2006.01) C07K 5/087 (2006.01) C07K 5/09 (2006.01) C07K 5/093 (2006.01) C07K 5/097 (2006.01) C07K 5/10 (2006.01) C07K 5/103 (2006.01) C07K 5/107 (2006.01) C07K 5/11 (2006.01) C07K 7/06 (2006.01) C07K 14/78 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2177840

The present invention contemplates a peptide that inhibits the binding between the VLA-4 receptor expressed on inflammatory leukocytes and the fibronectin CS-1 peptide expressed on endothelial cells that are involved in immunoinflammatory disease states. Pharmaceutical compositions containing a contemplated peptide and processes for treating immunoflammatory conditions using a binding- inhibitory peptide are also disclosed.

L'invention concerne un peptide qui inhibe la fixation entre le récepteur VLA-4 exprimé sur les leucocytes inflammatoires et le peptide CS-1 de la fibronectine exprimé sur les cellules endothéliales qui sont impliqués dans les maladies immunoinflammatoires. L'invention a également pour objet des compositions pharmaceutiques contenant un peptide et des procédés pour traiter les états immunoinflammatoires à l'aide d'un peptide inhibiteur de la fixation.

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