Csf-1r inhibitors compositions, and mthods of use

Details Csf-1r inhibitors compositions, and mthods of use Csf-1r inhibitors compositions, and mthods of use

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/395 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61K 31/517 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2702699

Disclosed herein are compounds and their oxides, esters, prodrugs, solvates, and pharmaceutically acceptable salts thereof, compositions of the compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier, and uses of the compounds, either alone or in combination with at least one additional therapeutic agent. The embodiments are useful for inhibiting cellular proliferation, inhibiting the growth and/or metathesis of tumors, treating or preventing cancer, treating or preventing degenerating bone diseases such as rheumatoid arthritis, and/or inhibiting molecules such as CSF-1R.

La présente invention concerne des composés et leurs oxydes, des esters, des promédicaments, des solvates et des sels pharmaceutiquement acceptables de ceux-ci. L'invention concerne également des compositions de ces composés, seuls ou en combinaison avec au moins un agent thérapeutique supplémentaire, avec un vecteur pharmaceutiquement acceptable. L'invention porte en outre sur des utilisations de ces composés, seuls ou en combinaison avec au moins un agent thérapeutique supplémentaire. Les modes de réalisation de la présente invention sont utiles dans l'inhibition de la prolifération cellulaire, l'inhibition de la croissance et/ou de la métathèse des tumeurs, le traitement ou la prévention du cancer, le traitement ou la prévention de maladies osseuses dégénératives telles que l'arthrite rhumatoïde, et/ou l'inhibition de molécules telles que CSF-1R.

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