C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/38 (2006.01) A61K 39/245 (2006.01) A61P 31/20 (2006.01) C07K 7/06 (2006.01) C07K 14/05 (2006.01) C12N 15/11 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2294732
The present invention provides cytotoxic Epstein-Barr virus (EBV) T-cell epitopes derived from EBV structural antigens. Preferred epitopes include YLLEMLWRL (SEQ ID NO:1), YFLEILWGL (SEQ ID NO:32), YLLEILWRL (SEQ ID NO:33), YLQQNWWTL (SEQ ID NO:6), LLLALLFWL (SEQ ID NO:2), LLVDLLWLL (SEQ ID NO:3), LLLIALWNL (SEQ ID NO:4), WLLLFLAIL (SEQ ID NO:5), TLLVDLLWL (SEQ ID NO:7), LLWLLLFLA (SEQ ID NO:8), ILLIIALYL (SEQ ID NO:9), VLFIFGCLL (SEQ ID NO:10), RLGATIWQL (SEQ ID NO:11), ILYFIAFAL (SEQ ID NO:15), SLVIVTTFV (SEQ ID NO:17), LMIIPLINV (SEQ ID NO:20), TLFIGSHVV (SEQ ID NO:24), LIPETVPYI (SEQ ID NO:26), VLQWASLAV (SEQ ID NO:27) and QLTPHTKAV (SEQ ID NO:29). The present invention also provides methods of treating or preventing EBV infection in subjects which involve administration of EBV cytotoxic T-cell epitopes.
La présente invention concerne des épitopes de lymphocytes T cytotoxiques du virus Epstein Barr, dérivés des antigènes structurels de ce virus. Les épitopes préférés comprennent YLLEMLWRL (SEQ ID No:1), YFLEILWGL (SEQ ID No:32), YLLEILWRL (SEQ ID No:33), YLQQNWWTL (SEQ ID No:6), LLLALLFWL (SEQ ID No:2), LLVDLLWLL (SEQ ID No:3), LLLIALWNL (SEQ ID No:4), WLLLFLAIL (SEQ ID No:5), TLLVDLLWL (SEQ ID No:7), LLWLLLFLA (SEQ ID No:8), ILLIIALYL (SEQ ID No:9), VLFIFGCLL (SEQ ID No:10), RLGATIWQL (SEQ ID No:11), ILYFIAFIAL (SEQ ID No:15), SLVIVTTFV (SEQ ID No:17), LMIIPLINV (SEQ ID No:20), TLFIGSHVV (SEQ ID No:24), LIPETVPYI (SEQ ID No:26), VLQWASLAV (SEQ ID No:27) et QLTPHTKAV (SEQ ID No:29). La présente invention concerne également des procédés pour traiter ou prévenir l'infection par le virus Epstein Barr chez des sujets, qui consistent à administrer à ces derniers des épitopes de lymphocytes T cytotoxiques du virus Epstein Barr.
Burrows Scott Renton
Khanna Rajiv
Sherritt Martina Alison
Commonwealth Scientific And Industrial Research Organisation
Csl Limited
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The Council Of The Queensland Institute Of Medical Research
The University Of Melbourne
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