Ctla4 receptor, fusion proteins containing it and uses thereof

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/395 (2006.01) A61P 37/02 (2006.01)

Patent

CA 2580812

The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.

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