Ctp modified gonadotropic proteins

Details Ctp modified gonadotropic proteins Ctp modified gonadotropic proteins

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/20 (2006.01) A61K 38/24 (2006.01) A61K 38/28 (2006.01) C07K 1/107 (2006.01) C07K 14/435 (2006.01) C07K 14/59 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2160800

"Partial" and "complete" CTP units are used to modify biologically active proteins and peptides to alter their clearance patterns. "Complete" CTP units have the amino acid sequence found at positions 112-118 to position 145 of the .beta.-subunit of human chorionic gonadotropin; "partial" CTP units are missing at least one amino acid in the region of position 118-145 inclusive. Variants of these CTP units contain 1-5 conservative amino acid substitutions which do not destroy activity. Suitable peptides or proteins which may be modified in this manner include various hormones and cytokines.

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