Cucurbiturils and method for synthesis

C - Chemistry – Metallurgy – 07 – D

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C07D 487/22 (2006.01) C07D 471/22 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2373159

A method for producing cucurbit[n]urils, where n is from 4 to 12, comprising mixing substituted and/or unsubstituted glycoluril with an acid and a compound that can form methylene bridges between glycoluril units, and heating the mixture to a temperature of from 20~ to 120~ to thereby form cucurbit[n]. Novel cucurbit[n]urils, where n = 4, 5, 7, 8, 9, 10, 11 and 12 and substituted cucurbit[s,u]urils, where s = number of substituted glycoluril units, u = number of unsubstituted units and s + u = 4 - 12 are also described.

L'invention concerne un procédé permettant de produire des cucurbit[n]uriles, dans lesquels n est un nombre allant de 4 à 12. Ce procédé consiste à mélanger du glycolurile substitué et/ou non substitué avec un acide et un composé capable de former des ponts méthylène entre les motifs glycolurile, et à chauffer ce mélange à une température comprise entre 20· et 120· afin de former du cucurbit[n]. L'invention concerne également de nouveaux cucurbit[n]uriles, dans lesquels n = 4, 5, 7, 8, 9, 10, 11 et 12 et des cucurbit[s,u]uriles substitués, dans lesquels s = nombre de motifs glycolurile substitués, u = nombre de motifs non substitués et s + u = 4 12.

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