Cultured and encapsulated pancreatic stem cells

Details Cultured and encapsulated pancreatic stem cells Cultured and encapsulated pancreatic stem cells

A - Human Necessities

61

K

A61K 35/39 (2006.01) C12N 5/071 (2010.01) A61K 9/48 (2006.01) A61L 27/38 (2006.01) A61P 3/10 (2006.01) C12N 11/04 (2006.01) A61K 9/16 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2470400

This invention relates to the discovery that an intermediate, differentiated stage of pancreatic stem cells exist that can be matured in situ into a stable cell line that produces insulin in response to glucose. These cells are advantageous in that they are both expandable and stable in culture. This invention avoids the step of culturing the intermediate stage stem cells into later stage pancreatic cells.

On a découvert que dans une étape intermédiaire différenciée, des cellules souches pancréatiques existantes peuvent mûrir in situ dans une lignée cellulaire qui produit de l'insuline en réponse au glucose. Ces cellules sont avantageuses en ce qu'elles sont à la fois extensibles et stables en culture. Cette invention permet d'éviter l'étape de culture de cellules souches intermédiaires dans des cellules pancréatiques au cours d'une étape ultérieure.

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