A - Human Necessities – 01 – K
Patent
A - Human Necessities
01
K
A01K 67/027 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12N 15/87 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2250834
Novel cultured inner cell mass (CICM) cells, and cell lines, derived from ungulates, in particular, pigs and cows, and methods for their preparation are provided. The subject CICMs possess similar morphology and express cell markers identically or substantially similarly to ICMs of undifferentiated developing embryos for prolonged culturing periods. Heterologous DNAs may be introduced into the subject CICM cells and cell lines to produce transgenic cells useful for the production of transgenic embryos, fetuses and/or offspring, e.g., by nuclear transfer procedures.
L'invention concerne des cellules à bouton embryonnaire cultivé et des lignées de cellules, dérivées d'ongulés - en particulier de truies et de vaches -, et des procédés pour les préparer. Ces boutons embryonnaires cultivés possèdent une morphologie similaire et expriment des marqueurs de cellules de manière identique ou sensiblement similaire aux bouton embryonnaires d'embryons en développement non différenciés, pendant des périodes de culture prolongées. Des ADN hétérologues peuvent être introduits dans lesdites cellules à bouton embryonnaire cultivé et dans lesdites lignées cellulaires pour créer des cellules transgéniques utilisées pour produire des embryons, des foetus ou des descendants transgéniques, par exemple par des techniques de transfert nucléaire.
Golueke Paul J.
Stice Steven L.
As Represented By Its Amherst Campus University Of Massachusetts A. Public Institution Of Higher Educ
Gowling Lafleur Henderson Llp
LandOfFree
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