C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/63 (2006.01) A61P 35/00 (2006.01) C07C 33/48 (2006.01) C07C 45/29 (2006.01) C07C 45/62 (2006.01) C07C 45/74 (2006.01) C07C 49/233 (2006.01) C07C 49/235 (2006.01) C07C 49/248 (2006.01) C07C 49/255 (2006.01) C07C 49/697 (2006.01) C07C 49/747 (2006.01) C07C 49/753 (2006.01) C07C 225/22 (2006.01) C07C 235/34 (2006.01) C07C 251/40 (2006.01) C07C 275/24 (2006.01) C07C 317/10 (2006.01) C07C 321/20 (2006.01) C07D 209/34 (2006.01) C07D 295/205 (2006.01) C07D 317/50 (2006.01) C07D 451/02 (2006.01)
Patent
CA 2393440
The present invention is directed to curcumin analogs (I), wherein Y is OH, halogen, or CF3; Z is H, OH, OR1, halogen, or CF3; X1 and X2 are independently C or N; and A is as defined in the application; exhibiting anti-tumor and anti- angiogenic properties, pharmaceutical formulations including such compounds and methods of using such compounds.
La présente invention concerne des analogues de circumine (I) dans laquelle Y est OH, halogène ou CF¿3?; Z est H, OH, OR1, halogène ou CF¿3?; X¿1? et X¿2? sont indépendamment C ou N et A est défini dans l'application; ces analogues ont des propriétés anti-angiogéniques et antitumorales. L'invention concerne aussi des formulation comprenant ces composés et des procédés d'utilisation correspondants.
Adams Brian
Davis Matthew C.
Ferstl Eva M.
Liotta Dennis C.
Shoji Mamoru
Emory University
Smart & Biggar
LandOfFree
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