Curcumin and curcuminoid inhibition of angiogenesis

Details Curcumin and curcuminoid inhibition of angiogenesis Curcumin and curcuminoid inhibition of angiogenesis

A - Human Necessities

61

K

A61K 31/12 (2006.01) A61K 31/198 (2006.01) A61K 31/336 (2006.01) A61K 31/341 (2006.01) A61K 31/404 (2006.01) A61K 31/454 (2006.01)

Patent

CA 2377141

Methods for treating diseases or disorders of the skin which are characterized by angiogenesis have been developed using curcumin and curcumin analogs. Based on the results obtained with curcumin, it has been determined that other angiogenesis inhibitors can also be used to treat these skin disorders. It has further been discovered that curcumin acts to inhibit angiogenesis in part by inhibition of basic fibroblast growth factor (bFGF), and thereby provides a means for treating other disorders characterized by elevated levels of bFGF, such as bladder cancer, using curcumin and other analogues which also inhibit bFGF. Representative skin disorders to be treated include the malignant diseases angiosarcoma, hemangioendothelioma, basal cell carcinoma, squamous cell carcinoma, malignant melanoma and Karposi's sarcoma, and the non- malignant diseases or conditions including psoriasis, lymphangiogenesis, hemangioma of childhood, Sturge-Weber syndrome, verruca vulgaris, neurofibromatosis, tuberous sclerosis, pyogenic granulomas, recessive dystrophic epidermolysis bullosa, venous ulcers, acne, rosacea, eczema, molluscum contagious, seborrheic keratosis, and actinic keratosis.

L'invention concerne des méthodes de traitement de maladies ou de troubles cutanés caractérisés par l'angiogenèse, dans lesquelles sont utilisées la curcumine et des analogues de la curcumine. A partir des résultats obtenus avec la curcumine, on a déterminé que d'autres inhibiteurs d'angiogenèse peuvent également être utilisés pour traiter ces troubles cutanés. On a également découvert que, pour inhiber l'angiogenèse, la curcumine agit en partie par inhibition du facteur de base de croissance des fibroblastes (bFGF) et constitue ainsi un moyen de traiter d'autres troubles caractérisés par des niveaux élevés de bFGF, par exemple le cancer de la vessie, grâce à l'utilisation de la curcumine et d'autres analogues également inhibiteurs du bFGF. Les troubles cutanés représentatifs à traiter incluent les affections malignes comme l'angiosarcome, l'hémangio-endothéliome, l'épithélioma basocellulaire, l'épithélioma spinocellulaire, les mélanomes malins et le sarcome de Karposi, et les affections ou états pathologiques bénins comme le psoriasis, la lymphangiogenèse, l'hémangiome de l'enfance, le syndrome de Sturge-Weber, les verrues, la neurofibromatose, la sclérose tuberculeuse, les granulomes pyogènes, l'épidermolyse bulleuse dystrophique récessive, les ulcères veineux, l'acné, l'acné rosacée, l'eczéma, le molluscum contagieux, la kératose séborrhéique, et la kératose actinique.

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