Custom-made meganuclease and use thereof

Details Custom-made meganuclease and use thereof Custom-made meganuclease and use thereof

C - Chemistry, Metallurgy

12

N

C12N 9/22 (2006.01) A01H 1/00 (2006.01) A01K 67/027 (2006.01) A61K 48/00 (2006.01) C12N 15/10 (2006.01) C12N 15/55 (2006.01) C12N 15/85 (2006.01) C12N 15/90 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2514417

New rare-cutting endonucleases, also called custom-made meganucleases, which recognize and cleave a specific nucleotide sequence, derived polynucleotide sequences, recombinant vector cell, animal, or plant comprising said polynucleotide sequences, process for producing said rare-cutting endonucleases and any use thereof, more particularly, for genetic engineering, antiviral therapy and gene therapy.

L'invention se rapporte à de nouvelles endonucléases rares, également appelées méganucléases sur mesure, qui reconnaissent et coupent une séquence nucléotidique spécifique, à des séquences polynucléotidiques dérivées, à un vecteur de recombinaison, à une cellule, un animal ou une plante comprenant lesdites séquences polynucléotidiques, à un procédé de production desdites endonucléases rares et à toute utilisation desdites endonucléases rares, plus particulièrement, à des fins d'ingénierie génomique, de thérapie antivirale et de thérapie génique.

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