C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/517 (2006.01) A61P 29/00 (2006.01) A61P 37/02 (2006.01) C07D 235/14 (2006.01) C07D 239/91 (2006.01) C07D 249/12 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 413/14 (2006.01) C07F 7/10 (2006.01)
Patent
CA 2431553
Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes.
La présente invention concerne des composés, des compositions et des procédés utiles dans le traitement des conditions et des maladies inflammatoires et immunitaires. En particulier, l'invention propose des composés qui modulent l'expression et/ou la fonction d'un récepteur de chimiokines. Les procédés de l'invention sont utiles pour le traitement des troubles et des maladies inflammatoires et immunorégulateurs, tels que la sclérose en plaques, la polyarthrite rhumatoïde et le diabète insulino-dépendant.
Huang Alan Xi
Johnson Michael G.
Li An-Rong
Liu Jiwen
Marcus Andrew P.
Amgen Inc.
Osler Hoskin & Harcourt Llp
Tularik Inc.
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