Cxcr3 is a gliadin receptor

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/705 (2006.01)

Patent

CA 2598146

Gliadin is identified as a physiological receptor for CXCR3. Assays for determining modulators of CXCR3 signaling are provided. Fragments of gliadin which function as inhibitors of CXCR3 signaling can be determined. Methods for treating diseases relating to gluten and/or autoimmunity by targeting CXCR3 are provided. Such diseases include celiac disease, gluten sensitivity, gluten allergy, rheumatoid arthritis, multiple sclerosis, immune-mediated or type 1 diabetes mellitus, inflammatory bowel diseases, systemic lupus erythematosus, psoriasis, scleroderma, and autoimmune thyroid diseases.

La gliadine est identifiée en tant que récepteur physiologique pour CXCR3. Des analyses permettant de déterminer des modulateurs de la signalisation de CXCR3 sont décrits. Des fragments de gliadine qui fonctionnent en tant qu'inhibiteurs de la signalisation de CXCR3 peuvent être déterminés. Des méthodes de traitement de maladies liées au gluten et / ou à l'auto-immunité par ciblage de CXCR3 sont également décrites. Ces maladies comprennent la maladie coeliaque, la sensibilité au gluten, l'allergie au gluten, l'arthrite rhumatoïde, la sclérose en plaques, le diabète sucré à médiation immune ou de type 1, les maladies inflammatoires de l'intestin, le lupus érythémateux disséminé, le psoriasis, la sclérodermie et les maladies thyroïdiennes auto-immunes.

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