Cxcr4 antagonists and methods of their use

Details Cxcr4 antagonists and methods of their use Cxcr4 antagonists and methods of their use

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 31/7105 (2006.01) A61K 38/10 (2006.01) A61K 47/22 (2006.01) A61P 35/00 (2006.01) C12Q 1/04 (2006.01) G01N 21/64 (2006.01)

Patent

CA 2520406

Compositions and methods for the treatment or prevention of a chemokine~ related or chemokine-receptor-related pathology are provided. In one aspect, the pathology is cancer. It has been discovered that CXCR4 antagonists, in particular CXCR4 peptide antagonists such as TN14003, inhibit or reduce tumor metastasis in a host.

L'invention concerne des compositions et des méthodes de traitement ou de prévention d'une pathologie associée à la chimiokine ou au récepteur de la chimiokine. Selon une variante, la pathologie est un cancer. On a découvert que les antagonistes CXCR4, plus particulièrement les antagonistes de peptide CXCR4, notamment TN14003, inhibent ou réduisent la métastase cancéreuse chez un hôte.

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