Cxcr4 antagonists for the treatment of medical disorders

Details Cxcr4 antagonists for the treatment of medical disorders Cxcr4 antagonists for the treatment of medical disorders

C - Chemistry, Metallurgy

07

D

C07D 239/28 (2006.01) A61K 31/506 (2006.01)

Patent

CA 2593578

The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor for the treatment of proliferative conditions mediated by CXCR4 receptors. The compounds provided interfere with the binding of SDFl to the receptor. These compounds are particularly, useful for treating or reducing the severity of hyperproliferative diseases by inhibiting metastasis.

L'invention concerne des composés, des compositions pharmaceutiques et des procédés d'utilisation de certains composés qui sont des antagonistes du récepteur de chémokine CXCR4 destinés au traitement d'états prolifératifs médiés par les récepteurs CXCR4. Les composés de l'invention entravent la liaison du SDF1 avec le récepteur. Les composés précités sont particulièrement utiles pour traiter ou réduire la sévérité des maladies hyperprolifératives en inhibant les métastases.

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