Cxcr4 antagonists for wound healing and re-epithelialization

Details Cxcr4 antagonists for wound healing and re-epithelialization Cxcr4 antagonists for wound healing and re-epithelialization

A - Human Necessities

61

K

A61K 38/10 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 17/02 (2006.01)

Patent

CA 2649253

The present invention provides novel uses for CXCR4 antagonists, including specifically peptides of the T-140 family, in the treatment of skin burns and other injuries. The invention further provides methods for increasing epithelialization in a subject in need thereof, and for preventing or inhibiting fibrosis and excessive scar formation, using peptide inhibitors of the T-140 family as well as other CXCR4 antagonists.

La présente invention porte sur de nouvelles utilisations des antagonistes de CXCR4, comprenant spécifiquement des peptides de la famille T-140, dans le traitement des brûlures cutanées et autres lésions. L'invention porte également sur des méthodes visant à accroître l'épithélialisation chez un sujet, et à prévenir ou inhiber la fibrose et la formation excessive d'escarres en utilisant des inhibiteurs peptidiques de la famille T-140, ainsi que d'autres antagonistes de CXCR4.

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