Cxcr4 chemokine receptor binding compounds

Details Cxcr4 chemokine receptor binding compounds Cxcr4 chemokine receptor binding compounds

C - Chemistry, Metallurgy

07

D

C07D 401/02 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01)

Patent

CA 2520259

The present invention relates to compounds that bind to chemokine receptors, and having the formula (I) wherein each A, X, Y, R1, R2 and R3 are substituents. The present invention also relates to methods of using such compounds, such as in treating HIV infection and inflammatory conditions such as rheumatoid arthritis. Furthermore, the present invention relates to methods to elevate progenitor and stem cell counts, as well as methods to elevate white blood cell counts, using such compounds.

La présente invention a trait à des composés de liaison aux récepteurs de chimiokine de formule (I), dans laquelle : chaque A, X, Y, R?1¿, R?2¿ et R?3¿ sont des substituants. La présente invention a également trait à des procédé d'utilisation de tels composés, tels que dans le traitement d'infection à VIH et de conditions inflammatoires tels que la polyarthrite rhumatoïde. La présente invention a trait en outre à des procédés pour l'accroissement des numérations de cellules souches et embryonnaires, ainsi qu'à des procédés pour l'accroissement des numérations des globules blancs, mettant en oeuvre de tels composés.

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