Cyanamides useful as reversible inhibitors of cysteine...

Details Cyanamides useful as reversible inhibitors of cysteine... Cyanamides useful as reversible inhibitors of cysteine...

C - Chemistry, Metallurgy

07

D

C07D 295/18 (2006.01) A61K 31/275 (2006.01) A61K 31/535 (2006.01) A61P 19/10 (2006.01) A61P 29/00 (2006.01) C07C 261/04 (2006.01) C07D 217/06 (2006.01) C07D 295/185 (2006.01)

Patent

CA 2477692

Compounds according to the following formula (I): wherein the variables Q and Rl to R6 are as described herein, which reversibly inhibit the cysteine proteases, such as cathepsins K, S, F, L and B; pharmaceutical compositions containing such compounds, and method of treating diseases and pathological conditions exacerbated by these cysteine proteases such as, but not limited to rheumatoid arthritis, multiple sclerosis and other autoimmune diseases, osteoporosis, asthma, Alzheimer's disease, atherosclerosis and endometriosis.

L'invention concerne des composés représentés par la formule (I), dans laquelle les variables Q et R¿1? à R¿6? correspondent aux significations indiquées le descriptif. Ces composé inhibent de manière réversible les cystéine protéases telles que les cathepsines K, S, F, L et B. L'invention concerne également des compositions pharmaceutiques contenant ces composés et des méthodes permettant le traitement de maladies et d'états pathologiques exacerbés par ces cystéine protéases notamment, mais non exclusivement, la polyarthrite rhumatoïde, la sclérose en plaques et d'autres maladies auto-immunes, l'ostéoporose, l'asthme, la maladie d'Alzheimer, l'athérosclérose et l'endométriose.

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