Cyanoalkylamino derivatives as protease inhibitors

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 255/29 (2006.01) A61K 31/277 (2006.01) C07C 317/44 (2006.01) C07C 321/28 (2006.01) C07C 323/60 (2006.01) C07C 323/65 (2006.01) C07D 211/58 (2006.01) C07D 213/32 (2006.01) C07D 213/40 (2006.01) C07D 213/70 (2006.01) C07D 213/74 (2006.01) C07D 213/81 (2006.01) C07D 213/82 (2006.01) C07D 233/84 (2006.01) C07D 239/38 (2006.01) C07D 241/04 (2006.01) C07D 263/58 (2006.01) C07D 277/16 (2006.01) C07D 277/42 (2006.01) C07D 277/74 (2006.01) C07D 307/38 (2006.01) C07D 333/20 (2006.01)

Patent

CA 2466115

The present invention is directed to novel cyanoalkylamino derivatives that are inhibitors of cysteine protease such as cathepsins K, S, B and L, in particular cathepsin K. Pharmaceutical composition comprising these compounds, method of treating diseases mediated by unregulated cysteine protease activity, in particular cathepsin K, utilizing these compounds and methods of preparing these compounds are also disclosed.

Cette invention se rapporte à de nouveaux dérivés cyanoalkylamino qui sont des inhibiteurs de la cystéine-protéase, tels que les cathepsines K, S, B et L, notamment la cathepsine K. cette invention concerne également une composition pharmaceutique contenant ces composés, un procédé pour traiter des maladies induites par une activité de la cystéine-protéase non régulée, notamment la cathepsine K, à l'aide de ces composés, ainsi que des procédés pour préparer ces composés.

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