C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/72 (2006.01) A61K 31/341 (2006.01) A61K 31/357 (2006.01) A61K 31/381 (2006.01) A61K 31/428 (2006.01) C07D 235/28 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2533763
The present invention provides methods for the use of compounds as depicted by structure (I), pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.
La présente invention concerne des procédés pour l'utilisation de composés tels que décrits par la structure (I), des compositions pharmaceutiques les contenant ainsi que des méthodes de prophylaxie, de gestion et de traitement de maladies métaboliques et de maladies modulées par l'inhibition de MCD. Les composés décrits dans cette invention sont utiles dans la prophylaxie, la gestion et le traitement de maladies intervenant dans la voie du métabolisme du glucose/acide gras régulé par malonyl-CoA. En particulier, ces composés et la composition pharmaceutique les contenant sont indiqués dans la prophylaxie, la gestion et le traitement de maladies cardio-vasculaires, du diabète, du cancer et de l'obésité.
Dyck Jason R.
Kafka Mark D.
Lopaschuk Gary D.
Russell Anna
Wilson Mark E.
Chugai Seiyaku Kabushiki Kaisha
Torys Llp
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