Cyanofluoropyrrolidine derivatives

Details Cyanofluoropyrrolidine derivatives Cyanofluoropyrrolidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 207/16 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/4155 (2006.01) A61K 31/4184 (2006.01) A61K 31/4192 (2006.01) A61K 31/422 (2006.01) A61K 31/428 (2006.01) A61K 31/433 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61K 31/498 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 5/50 (2006.01) A61P 13/08 (2006.01) A61P 17/00 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) A61P 43/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2

Patent

CA 2525442

A cyanofluoropyrrolidine compound represented by the following formula (I): (wherein A represents hydrogen or fluorine; R1 and R2 are the same as defined in the description; X represents a single bond or C1-3 alkylene; and R3 represents -N(R4)COR5, -N(R4)SO2R5, etc.), a pharmaceutically acceptable salt of the compound, or a hydrate of the compound. They are useful as a preventive or therapeutic agent for diseases or states which can be alleviated by inhibiting dipeptydyl peptidase IV (DPPIV) and for diabetes, immunologic diseases, etc.

L'invention concerne un composé cyanofluoropyrrolidine correspondant à la formule (I), un sel pharmaceutiquement acceptable de ce composé ou un hydrate de ce composé. Dans ladite formule (I), A représente hydrogène ou fluor, R?1¿ et R?2¿ correspondent à la définition donnée dans la description, X représente une liaison simple ou alkylène C¿1-3?, et R?3¿ représente N(R?4¿)COR?5¿, -N(R?4¿)SO¿2?R?5¿, etc. Ce dérivé, son sel pharmaceutiquement acceptable ou son hydrate peuvent être utilisés en tant qu'agent préventif ou thérapeutique pour des maladies ou des états qui peuvent être traités par inhibition de la dipeptydyle peptidase IV (DPPIV), pour le diabète, pour des maladies immunologiques, etc.

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