Cyanogen bromide cleavage of peptides

Details Cyanogen bromide cleavage of peptides Cyanogen bromide cleavage of peptides

C - Chemistry, Metallurgy

07

K

530/7.04

C07K 7/04 (2006.01) C07K 14/62 (2006.01)

Patent

CA 1251899

ABSTRACT OF THE DISCLOSURE Described herein is a process for inhibiting undesired thiol reactions of thiol-containing peptides, while preforming desirable thiol intermediates, during methionyl cleavage of said peptides using CNBr, by carrying out said cleavage in the presence of thio- sulfate ion.

453215

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