C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/72 (2006.01) A61K 31/428 (2006.01)
Patent
CA 2533881
The present invention provides methods for the use of compounds as depicted by structure (I), pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.
L'invention concerne des procédés d'utilisation de composés répondant à la structure (I), des compositions pharmaceutiques contenant ces composés, ainsi que des procédés utilisés pour la prophylaxie, la gestion et le traitement de maladies métaboliques et de maladies modulées par inhibition MCD. Les composés selon l'invention sont utilisés pour la prophylaxie, la gestion et le traitement de maladies intervenant dans un processus de métabolisme glucose/acide gras, régulé par le malonyl-CoA. En particulier, ces composés et la composition pharmaceutique les renfermant sont indiqués pour la prophylaxie, la gestion et le traitement de maladies cardiovasculaires, du diabète, du cancer et de l'obésité.
Arrhenius Thomas
Cheng Jie Fei
Dyck Jason R.
Liu Bin
Lopaschuk Gary D.
Chugai Seiyaku Kabushiki Kaisha
Torys Llp
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