Cyanoguanidine derivative and process for preparation thereof

Details Cyanoguanidine derivative and process for preparation thereof Cyanoguanidine derivative and process for preparation thereof

C - Chemistry, Metallurgy

07

C

260/540.3

C07C 323/44 (2006.01) C07D 233/54 (2006.01)

Patent

CA 1286318

CYANOGUANIDINE DERIVATIVE AND PROCESS FOR PREPARATION THEREOF Abstract Or the Disclosure The present invention provides a cyanoguanidine derivative which is a precursor for the synthesis of N- cyano-N'-methyl-N"-(2-{(5-methyl-1H-imidazol-4- yl)methylthio}ethyl)-guanidine (Cimetidine) or its related compound, which has an action of controlling secretion of scid in the stomach based on the histamine H2 receptor antagonism and is valuable as a drug for treating gastric ulcer. This cyanoguanidine derivative is prepared by reacting a haloketone derivative with an ammonium salt and a lower ratty acid salt or by reacting other cyanoguanidine derivative with an ammonium salt.

559037

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